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目的评估坦索罗辛联合双氯芬酸钠缓释片对老年男性输尿管下段结石体外冲击波碎石(ESWL)术后辅助排石作用的有效性及安全性。方法 149例单发阳性输尿管下段结石老年男性患者,结石6~15 mm,均接受ESWL治疗后,随机分成3组(组1、组2、组3),组1予以安慰剂治疗,组2予以坦索罗辛(0.2 mg,每晚顿服)治疗,组3予以坦索罗辛(0.2 mg,每晚顿服)及双氯芬酸钠缓释片(75 mg,1次/d)治疗。所有患者均随访1个月或结石完全排净或者至更改其他治疗方案。结果组2结石排净率、肾绞痛发生率分别与组1比较差异均有统计学意义(P<0.05),组3的结石排出时间、结石排净率、石街形成率、肾绞痛发生率、盐酸哌替啶使用率与组1比较差异有统计学意义(P均<0.05),同时组3的结石排净率高于组2(P=0.032),肾绞痛发生率、盐酸哌替啶使用率低于组2(P=0.031,0.039)。组2与组3的药物副作用比较差异无统计学意义(P=0.188)。结论坦索罗辛联合双氯芬酸钠缓释片用于老年男性输尿管下段结石ESWL术后辅助排石治疗是安全有效的。
Objective To evaluate the efficacy and safety of tamsulosin plus diclofenac sodium sustained-release tablets in post-operative pavement-assisted lithotripsy of elderly patients with lower ureteral stones undergoing extracorporeal shock wave lithotripsy (ESWL). Methods One hundred and ninety-nine patients with single ureteral calculi in the lower ureter were aged 6-15 mm. All patients underwent ESWL and were randomly divided into 3 groups (group 1, group 2 and group 3). Group 1 received placebo and group 2 received Tamsulosin (0.2 mg once daily), and tamsulosin 0.2 mg once daily in group 3 and diclofenac sodium sustained-release tablets 75 mg once daily. All patients were followed up for 1 month or stones were completely drained or changed to other treatment options. Results The rate of stone removal and the incidence of renal colic in group 2 were significantly different from those in group 1 (P <0.05), the time of stone discharge in group 3, the rate of stone removal, the stone street formation rate, renal colic (P <0.05), and the rate of stone removal in group 3 was higher than that in group 2 (P = 0.032). The incidence of renal colic, the incidence of renal colic, Pethidine was less active than Group 2 (P = 0.031, 0.039). There were no significant differences in side effects between groups 2 and 3 (P = 0.188). Conclusion Tamsulosin combined with diclofenac sodium sustained-release tablets is safe and effective in the treatment of elderly patients with lower ureteral calculi ESWL.