以３异丙基、３正戊基环戊二酮１，２为母体化合物，设计合成了９个未见文献报道的Ｍａｎｎｉｃｈ碱衍生物，并在体外进行了抗癌活性评价。初步药理活性筛选结果表明，３正戊基环戊二酮１，２Ｍａｎｎｉｃｈ碱衍生物的抗癌活性较强，３异丙基环戊二酮１，２Ｍａｎｎｉｃｈ碱衍生物的活性相对较弱，多数化合物的抗癌活性优于阳性对照药５Ｆｕ． Three 3-isopropyl, 3-n-pentylcyclopentanedione 1, 2 as the parent compound were designed and synthesized nine non-reported Mannich base derivatives, and in vitro anti-cancer activity was evaluated. The results of preliminary pharmacological activity screening showed that 3-n-pentylcyclopentadione-1, 2-Mannich base derivatives have strong anticancer activity, 3-isopropylcyclopentan-1, 2-Mannich base derivative activity is relatively Weak, the anticancer activity of most compounds is better than the positive control drug 5 Fu.