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目的 :探讨毒品依赖者患肺结核病人临床特点及预后情况。方法 :对 2 2例毒品依赖者患肺结核病进行了观察和追踪 ,分析其临床特点、实验室检查、治疗过程及预后并与随机选自同期住院及年龄相近的初治肺结核病人 40例进行对照。结果 :吸毒组病人临床表现为发热、气促、消瘦等症状明显 ,抗酸杆菌阳性率高 (占 63 6% ) ,X线胸片病灶广泛 ,占 3个及以上肺野患者多 (占 81 8% ) ,并发严重感染及合并乙肝、丙肝感染等疾病者多 ,分别占68 2 % ,5 4 5 % ,2 2 7% ,疗程需延长 (占 41 2 % ) ,病死率高 (占 2 2 7% ) ,均比对照组明显增高 ,差异有显著意义 (P <0 0 5 )。结论 :毒品依赖者患肺结核临床表现为病情重 ,合并症及并发症多 ,痰菌阳性率高 ,抗痨疗程需延长 ,效果欠佳 ,病死率高。
Objective: To investigate the clinical characteristics and prognosis of patients suffering from pulmonary tuberculosis caused by drug addicts. Methods: Twenty-two cases of drug-dependent pulmonary tuberculosis were observed and traced. The clinical features, laboratory tests, course of treatment and prognosis were analyzed and compared with 40 patients with newly diagnosed pulmonary tuberculosis . Results: The clinical manifestations of the drug addicts group were fever, shortness of breath, weight loss and so on. The positive rate of acid-fast bacilli was high (63.6%), the lesions of X-ray were extensive and accounted for more than 3 8%). The patients with severe infection and hepatitis B and hepatitis C infection accounted for 68.2%, 54.5% and 22.7% respectively. The duration of treatment was prolonged (41.2%) and the case fatality rate was high 2 7%) were significantly higher than the control group, the difference was significant (P <0 05). Conclusion: The clinical manifestations of tuberculosis in drug addicts are severe illness, complications and complications, the positive rate of sputum bacteria is high, the anti-tuberculosis treatment needs to be prolonged, the effect is poor and the case fatality rate is high.