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目的探讨盐酸帕洛诺司琼和盐酸托烷司琼预防晚期胃癌因全身化疗引起呕吐的疗效和安全性。方法采用随机对照双盲设计方法,选择60例含铂类和(或)5-Fu方案全身化疗的晚期胃癌患者,分别采用盐酸帕洛诺司琼和盐酸托烷司琼止吐,化疗后5d内观察患者呕吐状况及不良反应。结果化疗后24h内,盐酸帕洛诺司琼组0度呕吐为21例,盐酸托烷司琼组0度呕吐为13例。24～120h内,盐酸帕洛诺司琼组0度呕吐为18例,盐酸托烷司琼组0度呕吐为10例。使用盐酸帕洛诺司琼与盐酸托烷司琼后预防急性及延迟性呕吐的疗效比较差异均有统计学意义(P<0.05),而其不良反应比较差异无统计学意义。结论盐酸帕洛诺司琼预防晚期胃癌化疗所致呕吐的疗效优于盐酸托烷司琼,其不良反应发生率低,安全性好。
Objective To investigate the efficacy and safety of palonosetron hydrochloride and tropisetron hydrochloride in the prevention of vomiting induced by systemic chemotherapy in advanced gastric cancer. Methods Sixty patients with advanced gastric cancer who underwent systemic chemotherapy with platinum-based and / or 5-Fu regimen were selected. The patients were treated with palonosetron hydrochloride and tropisetron hydrochloride for 5 days Observed in patients with vomiting and adverse reactions. Results 24h after chemotherapy, palonosetron hydrochloride group 0 degrees vomiting was 21 cases, tropicone hydrochloride 0 degrees vomiting was 13 cases. In 24 ~ 120h, 0% vomiting in palonosetron hydrochloride group was 18 cases and 0% vomiting in tropisetron hydrochloride group was 10 cases. There were significant differences in the curative effect of palonosetron hydrochloride and tropisetron hydrochloride on preventing acute and delayed vomiting (P <0.05), but there was no significant difference in adverse reactions between them. Conclusion Palonosetron Hydrochloride is superior to tropisetron hydrochloride in the prevention of vomiting induced by chemotherapy of advanced gastric cancer with low incidence of adverse reactions and good safety.