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目的探讨万托林联合西米替丁辅助治疗婴幼儿毛细支气管炎的疗效及安全性。方法2007年9月～2008年2月在襄樊市中心医院万山分院收治的150例毛细支气管炎患儿,将他们分为治疗A组、治疗B组和常规治疗组。3组均采用综合治疗。常规治疗组用α-靡蛋白酶4000U雾化吸入,每日2次;治疗A组在常规组的基础上加用万托林雾化吸入,用量为0.5～1mL,2-3次/日,每次吸入10～15min,连用3～5d;治疗B组在A组基础上,加用西米替丁20～30mg/kg·d用5%葡萄糖注射液稀释后静滴1周。对3组临床症状、体征持续时间,住院时间以及疗效等进行对照评价。结果治疗B组治愈率明显提高,气促缓解、哮鸣音、湿口罗音、咳嗽症状消失及住院时间明显缩短,与常规治疗组比较差异有统计学意义(P<0.05或P<0.01)。治疗A组与常规组比较差异亦有统计学意义(P<0.05或P<0.01)。结论万托林联合西米替丁辅助治疗小儿毛细支气管炎可缩短病程,提高治愈率,疗效确切,使用安全。
Objective To investigate the efficacy and safety of vetolin combined with cimetidine in the treatment of infantile bronchiolitis. Methods From September 2007 to February 2008, 150 cases of bronchiolitis were treated in Wan Shan Branch of Xiangfan Central Hospital and divided into treatment A group, treatment B group and conventional treatment group. Three groups were treated with comprehensive treatment. Conventional treatment group with α-extravertase 4000U atomized inhalation, 2 times a day; treatment A group on the basis of the conventional group plus Wan Torin aerosol inhalation, the amount of 0.5 ~ 1mL, 2-3 times / day, each Inhalation 10 ~ 15min, once every 3 ~ 5d; treatment B group on the basis of group A, plus cimetidine 20 ~ 30mg / kg · d diluted with 5% glucose injection for 1 week. Three groups of clinical symptoms, signs of duration, duration of hospitalization and efficacy of controlled evaluation. Results The cure rate of group B was significantly higher than that of group B (P <0.05 or P <0.01). The cure rate of group B was significantly higher than that of group B (P <0.05 or P <0.01) . The difference between treatment group A and control group was also statistically significant (P <0.05 or P <0.01). Conclusion Vetolin combined with cimetidine treatment of bronchiolitis in children can shorten the course of disease and improve the cure rate, curative effect is exact, safe to use.