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目的观察E838联合环磷酰胺(CTX)抗淋巴瘤(LM)及其对CTX的减毒作用。方法建立LM荷瘤小鼠模型,实验分对照组、CTX、不同浓度E838组、不同浓度E838+CTX组,比较各组间的差别。结果所有E838治疗组瘤重明显小于对照组,联合用药组各项实验指标均好于CTX组。结论E838对LM有抑制作用,并对CTX有增效及提高机体免疫作用。
Objective To observe E838 combined with cyclophosphamide (CTX) anti-lymphoma (LM) and its attenuated effect on CTX. Methods The model of LM tumor-bearing mice was established. The experiment was divided into control group, CTX group, E838 group with different concentrations, and E838 + CTX group with different concentrations. The differences between the groups were compared. Results The tumor weight of all the E838 treatment groups was significantly smaller than that of the control group. The experimental indexes in the combination group were better than those in the CTX group. Conclusion E838 has inhibitory effect on LM and has synergism on CTX and enhances immune function.