1-三甲硅氧基膦酸酯是一类具有显著生物活性的有机硅磷化合物。具有药效长、毒性低等特点,采用含P—O—Si键的亚磷酸酯与羰基化合物反应的方法进行合成,反应条件温和,产率比较高,但需要先制备化学性质活泼的含硅基亚磷酸酯,而且反应要在惰性气体下进行,实施有所不便。本文直接采用三烷基亚磷酸酯(1)、α、β-不饱和醛(2)与三甲基氯硅烷进 1-trimethylsilylphosphonate is a class of organosilicon phosphorus compounds with significant biological activity. The invention has the advantages of long drug efficacy and low toxicity. The method comprises the steps of reacting the phosphite with the P-O-Si bond with the carbonyl compound for mild reaction conditions and high yield. However, Phosphite, and the reaction to be carried out under an inert gas, the implementation of some inconvenience. In this paper, direct use of trialkyl phosphite (1), α, β-unsaturated aldehyde (2) and trimethylchlorosilane into