以芳香醛、乙酰乙酸乙酯(甲酯)、单取代脲为原料,氯化亚锡为催化剂,在无溶剂、80℃条件下,通过三组分“一锅法”合成了一系列N1-取代的3,4-二氢嘧啶-2(1H)-酮衍生物。考察了催化剂用量和反应温度对产品收率的影响。通过IR、~1H NMR、~(13)C NMR和元素分析对目标产物结构进行确证,提出了可能的催化作用机理。本文的合成方法具有催化剂活性高、廉价易得和反应时间短、条件温和、产率高、绿色环保等优点。 Aromatic aldehydes, ethyl acetoacetate (methyl ester), monosubstituted urea as raw materials, stannous chloride as a catalyst, in the absence of solvent, 80 ℃ conditions, through the three-component N1-substituted 3,4-dihydropyrimidin-2 (1H) -one derivatives. The effects of the amount of catalyst and the reaction temperature on the yield of the product were investigated. The structure of the target product was confirmed by IR, ~ 1H NMR, ~ (13) C NMR and elemental analysis, and possible catalytic mechanism was proposed. The synthesis method of this paper has the advantages of high catalyst activity, cheap and easy to get and reaction time, mild conditions, high yield, environmental protection and so on.