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报道了以3-间硝基苯基/对硝基苯基-4-氨基-5-巯基-1,2,4-三唑与芳酸在磷酰氯的作用下,合成了16个标题化合物,并研究了合成反应的条件。观察了部分标题化合物对金黄色葡萄球菌和大肠杆菌有明显的抑菌作用。
Reported the title compound was synthesized with 3-nitrophenyl / p-nitrophenyl-4-amino-5-mercapto-1,2,4-triazole and aromatic acid in the presence of phosphorus oxychloride. The conditions of the synthesis reaction were also studied. Some of the title compounds were observed to have significant antibacterial activity against Staphylococcus aureus and Escherichia coli.