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笔者观察了肾功能处于不同时期（尿毒症期、氮质血症期、正常期）的患者葡萄糖耐量试验及胰岛素释放反应，结果发现：随着肾功能受损程度加重，糖耐量异党龄发生率明显增高（Ｐ＜０．０１），随着肾功能恶化，胰岛素释放异常的发生率亦逐渐升高（Ｐ＜０．０１）．常规血液透析后胰岛素释放指数（ＩＲＩ）较透析前明显升高（Ｐ＜０．００１）．此可能与血液透析后机体脱水较多，血液浓缩，而胰岛素作为中分子物质不易波血透短时间内充分清除有关。
The author observed in patients with different stages of renal function (uremia, azotemia period, the normal period) patients with glucose tolerance test and insulin release response, the results showed that: With the degree of renal impairment worse, allogeneic incidence of impaired glucose tolerance (P <0.01). As the renal function deteriorated, the incidence of abnormal insulin release increased gradually (P <0.01). Conventional hemodialysis insulin release index (IRI) was significantly higher than before dialysis (P <0.001). This may be dehydrated after hemodialysis more body, blood concentration, and insulin as a molecular material is not easy to completely eliminate the hemorrhage within a short period of time.