论文部分内容阅读
目的探讨老年社区获得性肺炎(community-acquired pneumonia,CAP)患者降钙素原(procalcitonin,PCT)、D-二聚体、超敏C反应蛋白(high-sensitivity C-reactive,hs-CRP)水平。方法收集2014年2月—2015年2月收治的103例老年社区获得性肺炎患者作为研究对象,测定患者入院第1天血清PCT、hs-CRP、D-二聚体水平。根据肺炎严重程度指数(pneumonia severity index,PSI)分为低危组43例、中危组39例、高危组21例;根据CURB-65评分分为1组46例、2组39例、3组18例;根据患者病情分为非重症肺炎组64例、重症肺炎组39例。比较各组PCT、hs-CRP、D-二聚体水平。计量资料采用t检验或方差分析,P<0.05为差异有统计学意义。结果不同PSI分级、CURB-65得分及病情严重程度各组患者PCT、hs-CRP、D-二聚体水平比较差异均有统计学意义(均P<0.05)。结论 PCT、hs-CRP、D-二聚体与老年CAP严重程度有一定的相关性,可作为判断病情的指标,并且PCT水平较稳定,不易受外界因素的干扰,因此PCT可以作为单一生物指标评估老年患者CAP的严重程度。
Objective To investigate the changes of procalcitonin (PCT), D-dimer and high-sensitivity C-reactive (hs-CRP) in community-acquired pneumonia (CAP) . Methods A total of 103 elderly patients with community-acquired pneumonia who were admitted to our hospital from February 2014 to February 2015 were enrolled in this study. Serum levels of PCT, hs-CRP and D-dimer were measured on the first day after admission. According to the pneumonia severity index (PSI), there were 43 cases in the low-risk group, 39 in the middle-risk group and 21 in the high-risk group. According to the CURB-65 score, there were 46 cases in one group, 39 cases in two groups, 18 cases; According to the patient's condition was divided into non-severe pneumonia group 64 cases, severe pneumonia group 39 cases. The levels of PCT, hs-CRP and D-dimer in each group were compared. Measurement data using t test or analysis of variance, P <0.05 for the difference was statistically significant. Results The levels of PCT, hs-CRP and D-dimer were significantly different among the groups with different PSI grade, CURB-65 score and severity of illness (all P <0.05). Conclusions PCT, hs-CRP and D-dimer have a certain correlation with the severity of CAP in the elderly, which can be used as an index to judge the disease. PCT is more stable and less susceptible to external factors, so PCT can be used as a single biological index Assess the severity of CAP in elderly patients.