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目的:优选骨舒胶囊的提取工艺。方法:采用正交试验方法对影响水提取醇沉工艺的各因素进行考察,以HPLC测定淫羊藿苷的含量作为优选工艺的考察指标。结果:优选的最佳工艺为药材加10倍量水,煎煮1 h,煎煮3次;醇沉时浸膏相对密度为1.08(60℃),药液温度为40℃,加醇至60%。结论:按正交试验优选的提取工艺可行,以淫羊藿苷为指标成分,能较好控制提取工艺的质量,方法简便实用。
Objective: To optimize the extraction process of Gu Shu capsule. Methods: The orthogonal test was used to investigate the factors influencing the process of water extraction and alcohol precipitation, and the content of icariin was determined by HPLC as the index of the optimum technology. Results: The optimum process was as follows: medicinal materials plus 10 times the amount of water, boiling 1 h, boiling 3 times; the alcohol precipitation when the relative density of 1.08 (60 ℃), the liquid temperature is 40 ℃, add alcohol to 60 %. Conclusion: According to the orthogonal experiment, the optimum extraction process is feasible. Using icariin as an index component, the quality of the extraction process can be controlled well. The method is simple and practical.