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Tri(o-bromobenzyl)tin diethyldithiocarbamate (1) and tri(m-fluorobenzyl)tin pyrrolidine dithiocarbamate (2) have been synthesized and characterized by elemental analysis,IR spectroscopy,NMR (1H,13C and 119Sn),thermogravimetric analysis and single-crystal X-ray diffraction.The two complexes crystallize in the triclinic system space group P(1).For complex 1,a =0.9770(1),b =1.1011(1),c =1.4583(1) nm,α =78.431(1)°,β =86.307(1)°,γ =69.712(1)°,V=1.4417(2) nm3,Z =2,Dc =1.790 g/cm3,μ(MoKα) =52.04 cm-1,F(000) =756,R=0.0434 and wR =0.0593.For complex 2,a =0.7055(1),b =1.3349(3),c =1.3782(3) nm,α =89.216(2)°,β =82.044(2)°,γ =84.637(2)°,V =1.2799(5) nm3,Z =2,Dc =1.537 g/cm3,μ(MoKα) =11.98 cm-1,F(000) =596,R=0.0313 and wR=0.0333.The two complexes represent mononuclear structures with five-coordinated [SnC3S2] cores forming a distorted trigonal bipyramid.The quantum chemical calculations of 1 and 2 have been investigated.The antitumor activity shows that 1 and 2 have higher activities than cisplatinum against Colo205,HepG2,MCF-7,Hela and H460 cell line in vitro.