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大内皮素(big-ET)是内皮素-1(ET-1)的具有活性的前体,测定它可以得到ETs最可靠的信息。为了确定ET是否是引起蛛网膜下腔出血(SAH)后血管痉挛的可能原因,作者应用放射免疫分析法对11例急性SAH病人头3周内的血浆和CSF进行了big-ET测定。其中男7例,女4例,均经CT、腰穿诊断为SAH并做了全脑血管造影,发现7例病人至少有1个动脉瘤作为出血的原因。big-ET测定的正常范围为1～11fmol/ml(1fmol=4.28pg)。病人血浆平均值为2.56±1.26fmol/ml,最高值7.26fmol/ml。CSF中最高值7.5fmol/ml。4例病人同时测定血浆和CSF的big-ET均在正常范围内,3例有严重血管痉挛的病人也没有显示big-ET增高。 作者指出,本文研究结果不支持SAH后病人血浆ET增高的假说。以前报告类似的ET增高所描
Big-ET, an active precursor of endothelin-1 (ET-1), determines the most reliable information on ETs when measured. To determine whether ET is a possible cause of vasospasm following subarachnoid hemorrhage (SAH), we performed a big-ET assay of plasma and CSF in 11 patients with acute SAH within the first 3 weeks using radioimmunoassay. Including 7 males and 4 females, all by CT, lumbar puncture diagnosis of SAH and made cerebral angiography and found that 7 patients had at least 1 aneurysm as the cause of bleeding. The normal range for big-ET assay is 1 to 11 fmol / ml (1 fmol = 4.28 pg). The average patient plasma was 2.56 ± 1.26 fmol / ml, the highest value of 7.26fmol / ml. CSF highest 7.5fmol / ml. In 4 patients, both big-ET in plasma and CSF were in the normal range, and in 3 patients with severe vasospasm, there was no increase in big-ET. The authors note that the results of this study do not support the hypothesis that plasma ET levels increase after SAH. Described previously for similar ET increases