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目的:探讨血管树突状细胞在人早期动脉粥样硬化(AS)病变中的分布模式。方法:人主动脉标本15例主要取自尸检和外科手术,常规连续切片,分别行HE及S100/CD1a免疫细胞化学染色,光镜下观察S100/CD1a阳性细胞分布情况。结果:15例HE染色标本中,2例正常,13例人动脉血管可见内膜的增厚及泡沫细胞等AS早期病理表现。9例S100/CD1a染色阳性,阳性率为69.2％。S100/CD1a阳性细胞分布在病变的内膜和外膜,外膜的S100/CD1a阳性细胞主要分布在滋养血管的周围。结论:在AS早期病变部位有血管树突状细胞的聚集,主要分布在病变血管的内膜和外膜,提示血管树突状细胞可能参与了AS早期的免疫反应。
Objective: To investigate the distribution pattern of vascular dendritic cells in early stage of human atherosclerosis (AS). Methods: Fifteen cases of human aortic specimens were taken from autopsy and surgery. The sections were routinely sectioned and stained with HE and S100 / CD1a respectively. The distribution of S100 / CD1a positive cells was observed under light microscope. Results: Among the 15 cases of HE staining, 2 cases were normal, 13 cases of human arteries showed intima thickening and early appearance of AS such as foam cells. Nine cases of S100 / CD1a positive staining, the positive rate was 69.2%. The S100 / CD1a positive cells were distributed in the intima and adventitia of the lesion. The S100 / CD1a positive cells in the adventitia mainly distributed around the nourishing vessels. Conclusion: There are vascular dendritic cells aggregated in the early stage of AS, which mainly distribute in the intima and adventitia of diseased vessels, suggesting that vascular dendritic cells may be involved in the early immune response of AS.