长期接触过量工业性神经毒物(如汞、锰等)常可出现手震颤。但临床上不能检查震颤的频率和振幅的细小变化。Miller于1977年对77名接触金属汞的工人前臂震颤作了大量的频谱分析,其中22人虽然临床上神经系统常规检查正常,但他们前臂震颤的频率增高。此后Langolf(1977)、Lippold Long-term exposure to industrial neurotoxic agents (such as mercury, manganese, etc.) can often occur hand tremor. However, small changes in the frequency and amplitude of tremor can not be clinically observed. Miller conducted extensive spectrum analyzes of 77 forearm tremorings in workers exposed to metallic mercury in 1977, and 22 of them had increased frequency of forearm tremor, although routine clinical examination of the nervous system was routine. Since then Langolf (1977), Lippold