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目的探讨根据DWI所得ADC值诊断前列腺中央腺体癌的标准。方法回顾性分析27例前列腺中央腺体癌患者(前列腺中央腺体癌组)和62例良性前列腺增生患者(良性前列腺增生组)的资料,测量两组患者的ADC值,绘制ROC曲线,寻找最佳临界点,确定中央腺体癌的ADC值的诊断标准。结果①中央腺体ADC值:前列腺中央腺体癌组为(1.22±0.20)×10-3mm2/s,良性前列腺增生组为(1.51±0.14)×10-3mm2/s,差异有统计学意义(t=-6.862,P<0.001);根据ROC分析,Youden指数最大为0.656,最佳临界点为1.316×10-3mm2/s,此时诊断前列腺中央腺体癌的敏感度为70.40%,特异度为95.20%,准确率为87.64%。②最小ADC值:前列腺中央腺体癌组为(0.82±0.16)×10-3mm2/s,良性前列腺增生组为(1.15±0.11)×10-3mm2/s,差异有统计学意义(t=-9.416,P<0.001);根据ROC分析,Youden指数最大为0.762,最佳临界点为0.953×10-3mm2/s,此时诊断前列腺中央腺体癌的敏感度为77.80%,特异度为98.40%,准确率为92.13%。结论制定ADC值标准有助于DWI诊断前列腺中央腺体癌。
Objective To investigate the diagnostic criteria of prostate gland carcinoma based on the ADC value of DWI. Methods The data of 27 patients with central glandular carcinoma of the prostate (prostate gland cancer group) and 62 patients with benign prostatic hyperplasia (benign prostatic hyperplasia) were retrospectively analyzed. The ADC values of the two groups were measured and the ROC curve was drawn to find the most Good cut-off point, to determine the central gland cancer ADC value of the diagnostic criteria. Results ① The ADC value of central gland was (1.22 ± 0.20) × 10-3mm2 / s in benign prostatic gland carcinoma group and (1.51 ± 0.14) × 10-3mm2 / s in benign prostatic hyperplasia group, the difference was statistically significant ( t = -6.862, P <0.001). According to ROC analysis, the maximum Youden index was 0.656 and the best cut-point was 1.316 × 10-3mm2 / s. The sensitivity of diagnosing prostate gland carcinoma was 70.40% 95.20%, the accuracy rate was 87.64%. ② The minimum ADC value was (0.82 ± 0.16) × 10-3mm2 / s in benign prostatic gland carcinoma group and (1.15 ± 0.11) × 10-3mm2 / s in benign prostatic hyperplasia group, the difference was statistically significant (t = 9.416, P <0.001). According to ROC analysis, the Youden index was 0.762 with the best critical point of 0.953 × 10-3mm2 / s. The sensitivity of diagnosis of central prostate cancer was 77.80% and the specificity was 98.40% , The accuracy rate is 92.13%. Conclusion The establishment of ADC value criteria will help DWI diagnosis of central prostate cancer.