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目的采用组织多普勒成像(TDI)纵向评估正常中晚孕同一胎儿不同孕周及新生儿期左、右室Tei指数的范围,并探讨Tei指数与孕周的关系。方法应用TDI测量100例同一正常孕妇的正常胎儿在不同孕周(22~24周、32~34周、36~38周)及新生儿期二、三尖瓣环的运动频谱,测量等容收缩时间(ICT)、等容舒张时间(IRT)、射血时间(ET),计算Tei指数,将同一胎儿不同孕周及新生儿期左、右心室Tei指数进行统计分析。结果正常胎儿不同孕周(22~24周、32~34周、36~38周)及新生儿期左、右心室Tei指数分别为0.452±0.054、0.452±0.057、0.418±0.065、0.368±0.061,0.453±0.045,0.453±0.054、0.399±0.056、0.316±0.069;左、右心室Tei指数不同时期间差别有统计学意义(P<0.05),34周前Tei指数随孕周增加无变化,34周后随孕周增加而下降,新生儿期进一步降低。结论 TDI测量Tei指数是一种简单、可靠、无创的定量综合评价心脏收缩和舒张功能的方法,同一正常孕妇的正常胎儿在不同孕周及新生儿期Tei指数测量值范围为未来研究各种病理状态下的胎儿、新生儿心功能异常提供可靠的常规对照指标。
Objective To evaluate the range of Tei index of left and right ventricle in different gestational age and neonatal period of the same fetus in normal middle and late pregnancy by tissue Doppler imaging (TDI), and to explore the relationship between Tei index and gestational age. Methods The TDI was used to measure the movement spectrum of the two tricuspid annulus in 100 pregnant women with the same normal pregnant women at different gestational weeks (22-24 weeks, 32-34 weeks, 36-38 weeks) and neonatal period, and the isokinetic contraction (ICT), isovolumic relaxation time (IRT) and ejection time (ET) were calculated. The Tei index was calculated and the Tei index of left and right ventricle in different gestational weeks and neonates of the same fetus was statistically analyzed. Results The Tei index of left ventricle and right ventricle of normal fetus at different gestation weeks (22-24 weeks, 32-34 weeks, 36-38 weeks) and neonatal period were 0.452 ± 0.054,0.452 ± 0.057,0.418 ± 0.065,0.368 ± 0.061, 0.453 ± 0.045,0.453 ± 0.054,0.399 ± 0.056,0.316 ± 0.069; Tei index of left ventricle and right ventricle did not change statistically between different periods (P <0.05) After gestational weeks increase and decline, to further reduce the neonatal period. Conclusion The TDI measurement of Tei index is a simple, reliable and noninvasive method for the quantitative and comprehensive evaluation of cardiac systolic and diastolic function. The range of Tei index of normal fetuses of the same normal pregnant women in different gestational weeks and neonatal period can be used to study various pathologies Status of the fetus, neonatal cardiac dysfunction provide reliable conventional control indicators.