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目的探讨子痫前期、妊娠期糖尿病患者、正常孕妇孕晚期血浆D-二聚体(D-dimer,D-D)水平及其指导临床治疗的意义。方法 D-D测定用免疫比浊法,分别测定子痫前期孕妇40例(轻度20例,重度20例)、妊娠期糖尿病20例、正常晚期妊娠孕妇(对照组)30例的血浆D-D水平。结果子痫前期孕妇、妊娠期糖尿病孕妇血浆D-D水平均较正常晚期妊娠孕妇组明显增高,差异有统计学意义(P<0.05);重度子痫前期孕妇血浆D-D水平明显高于轻度子痫前期组,差异有统计学意义(P<0.05)。结论子痫前期和妊娠期糖尿病患者血浆存在病理性高凝状态及继发性纤维蛋白溶解亢进,更倾向于血栓形成。而且,在子痫前期组轻、重度患者血液病理性高凝状态随病情严重程度而增高。因此,血浆D-D水平检测对产科病理性高凝状态疾病的监测、治疗具有重要临床意义。
Objective To investigate the level of plasma D-dimer (D-D) and its clinical significance in preeclampsia, gestational diabetes and normal pregnant women. Methods D-D was measured by immunoturbidimetry in 40 cases of preeclampsia (mild 20 cases, severe cases 20 cases), gestational diabetes mellitus (20 cases) and normal late pregnant women (control group), 30 cases of plasma D-D levels. Results The levels of plasma DD in preeclampsia and gestational diabetes mellitus were significantly higher than those in normal late pregnant women (P <0.05). The plasma levels of DD in pregnant women with severe preeclampsia were significantly higher than those in mild preeclampsia Group, the difference was statistically significant (P <0.05). Conclusions The plasma of patients with preeclampsia and gestational diabetes mellitus has pathological hypercoagulable state and secondary fibrinolysis, which is more inclined to thrombosis. Moreover, in the preeclampsia group of mild and severe patients with pathological hypercoagulability increased with the severity of the disease. Therefore, the detection of plasma D-D levels in obstetric pathological hypercoagulable state disease monitoring, treatment has important clinical significance.