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①目的研究人膀胱肿瘤对化疗药物反应性，筛选对个体敏感的化疗药物。②方法采用四氮唑蓝（ＭＴＴ）法对手术切除的２７例膀胱肿瘤新鲜标本进行顺铂（ＤＤＰ）、保尔佳（ｐｏｌｙｅｒｇａ）、丝裂霉素（ＭＭＣ）、噻替哌（ＴＨＴ）、阿霉素（ＡＤＭ）和足叶乙甙（ＶＰ－１６）的抗癌药物敏感试验。③结果２７例中对３种药物敏感者１０例，占３７．０％；敏感药物顺序依次为：ＤＤＰ，ｐｏｌｙｅｒｇａ，ＭＭＣ，ＴＨＴ，ＡＤＭ和ＶＰ－１６，与临床治疗结果大致相符。④结论ＭＴＴ法可以作为化疗药物敏感试验的检测方法，为临床科学合理地选择用药提供依据。
①Objective To study the responsiveness of human bladder cancer to chemotherapeutic drugs and to screen the chemotherapeutic drugs that are sensitive to the individual. Methods Twenty-seven freshly resected specimens of bladder tumor were treated with MTT (DDP, polyerga, mitomycin, thretide, Adriamycin (ADM) and etoposide (VP-16) anti-cancer drug sensitivity test. ③ Results Twenty-seven patients were sensitive to three drugs, accounting for 37.0%. The order of the sensitive drugs was DDP, polyerga, MMC, THT, ADM and VP-16, which were in good agreement with clinical results. ④ Conclusion MTT assay can be used as a sensitive test of chemotherapeutic drugs for clinical scientific and rational choice of medication to provide the basis.