纤维蛋白原是可溶性血浆糖蛋白,生理血浆浓度是2～4g/L,具有生理和病理的双重作用。在血液凝固的最后一步,在凝血酶的作用下,纤维蛋白原发生构象变化,聚合成不可溶的纤维蛋白。纤维蛋白原是血浆和血液粘滞度的主要决定因素。 流行病学的研究表明,极高浓度的纤维蛋白原增加了发生心血管疾病的危险。纤维蛋白原的浓度与急性动脉血栓的发生和复发有密切关系。这些动脉包括冠状动脉、外周动脉和脑动脉等。纤维蛋由原在形成 Fibrinogen is a soluble plasma glycoprotein, physiological plasma concentration is 2 ~ 4g / L, with a dual physiological and pathological effects. In the final step of blood clotting, the fibrinogen undergoes a conformational change under the action of thrombin and polymerizes into insoluble fibrin. Fibrinogen is a major determinant of plasma and blood viscosity. Epidemiological studies have shown that very high levels of fibrinogen increase the risk of developing cardiovascular disease. Fibrinogen concentration and acute arterial thrombosis are closely related to the occurrence and recurrence. These include coronary arteries, peripheral arteries and cerebral arteries. Fiber eggs formed by the original