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转化生长因子β在体内促进细胞外基质成分合成中起着重要的作用，同时也被认为是介导纤维增生性疾病的关键因子。作者综述了近年报道的转化生长因子β在肝、肾及肺器官纤维化疾病发生中所起的作用，探讨了器官纤维化新的和有效的防治途径和措施。
Transforming growth factor beta plays an important role in the synthesis of extracellular matrix components in vivo and is also considered to be a key factor in mediating fibrotic diseases. The authors review the recent reports on the role of transforming growth factor-β in the pathogenesis of fibrosis in the liver, kidney and lung and explore new and effective ways and means of preventing and treating organ fibrosis.