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多发性硬化是中枢神经系统炎症性自身免疫性疾病的典型代表,以白质脱髓鞘为主要特征。浆样树突状细胞,是专职抗原提呈细胞,是固有免疫和适应性免疫的桥梁,在启动初级免疫应答和维持免疫耐受中发挥了重要作用。由于浆样树突状细胞可以产生大量的细胞因子,特别是Ⅰ型干扰素,所以它与抗炎、免疫调节联系紧密。而目前Ⅰ型干扰素(β)被认为是治疗多发性硬化的有效的免疫调节剂。本文就浆样树突状细胞的来源、特性及其在固有免疫、适应性免疫及免疫耐受中的作用机制进行系统归纳整理,并就其未来发展前景做一简单介绍,为进一步探索免疫调节新机制和寻求多发性硬化新的治疗靶点提供理论依据和基础。
Multiple sclerosis is a typical manifestation of inflammatory autoimmune diseases of the central nervous system, with white matter demyelination as the main feature. Pulsed dendritic cells, which are specialized antigen-presenting cells, serve as a bridge between innate and adaptive immunity and play an important role in initiating primary immune responses and maintaining immune tolerance. Because plasma-like dendritic cells produce large amounts of cytokines, particularly type I interferons, they are closely linked to anti-inflammatory and immunomodulatory properties. At present, type I interferon (β) is considered as an effective immunomodulator for the treatment of multiple sclerosis. In this paper, the origin and characteristics of plasma-like dendritic cells and their mechanisms in innate immunity, adaptive immunity and immune tolerance were systematically summarized, and their future development prospects were briefly introduced. In order to further explore the immune regulation New mechanisms and seek new therapeutic targets for multiple sclerosis provide a theoretical basis and foundation.