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1928年 Shwartzman 发现,免皮内注射伤寒杆菌滤液后24小时静脉注射同一滤液,四小时内预先注射滤液的皮肤出现出血坏死损伤,同一部位皮肤内两次注射滤液并不引起这种损伤。后来把这种局部组织反应性改变的现象称为局部 Shwartzman 现象(LSP)。由于达一现象与临床上某些情况很相象,管有不少学者作了详细研究。但现有的文献多半只限于达一现象的描述,而有关共发病机制的研究为数较少。
In 1928 Shwartzman found that intravenous injection of the same filtrate 24 hours after intradermal injection of typhoid bacillus filtrate showed hemorrhagic and necrotic lesions in the skin of the prefilled filtrate within four hours and did not cause such lesions in the same site twice. Later, this phenomenon of local tissue reactivity change was called the local Shwartzman phenomenon (LSP). Due to the phenomenon of reaching a certain clinical situation is very similar, many scholars have made a detailed study. However, the existing literature is mostly limited to the description of the phenomenon of one phenomenon, and the study of co-pathogenesis is relatively small.