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应激是机体在内外环境、社会、心理等因素刺激时所发生的一种非特异性、适应性反应，应激能够影响动物和人体的免疫功能，进而人类导致许多传染性疾病、肿瘤及其他恶性疾病的发生。当今社会人们长期面临着工作节奏加快、竞争日益激烈、生活压力逐渐增大等因素的影响，心理应激越来越受到各国学者的重视，其与疾病发生、发展及治疗的关系已成为当今医学研究的热点。该文就近年来心理应激与免疫功能变化的研究现状进行综述。“,”Stress is the non-specific and adaptive response of the organisms to the environments whether they are internal,external or psychological-social.Stress can affect the immune function of ani-mal and human body,which is the direct cause of infectious diseases,cancer or deterioration.In mod-ern society, the physiological and psychological functions of human beings are affected by various kinds of stresses,such as speedy work pace,fierce competition and increase of life stress,et al.The role of psychological stress in the course of disease has been increasingly emphasized , about psychological stress in disease occurrence,development and treatment of research has become a hot spot in medical research.In this paper, the current research status of psychological stress and immune function relation-ship was reviewed.