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目的观察维持性血液透析患者血清骨保护素水平,并探讨其与血管钙化的相关性。方法选择2015年1月~2016年1月在潍坊市人民医院血液净化中心行规律血液透析治疗的60例患者作为研究对象,并选取30例健康体检者作为对照组,应用ELISA法测定各组患者血清骨保护素(OPG)水平;采用X线平片检查各组患者大动脉血管的钙化情况,并计算各个部位血管钙化积分。结果根据X线钙化评分将入选的60例MHD患者分为无钙化组(0分,21例,占MHD总人数的35%),轻度钙化组(~3分,共23例,占MHD总人数的38.3%),中度钙化组(~6分,共11例,占MHD总人数的18.3%),重度钙化组(~10分,共5人,占MHD总人数的8.4%),而对照组没有血管钙化的发生。在MHD患者中有血管钙化组OPG水平比无血管钙化组明显升高(P<0.05);中、重度血管钙化组的OPG比无钙化或轻度钙化组明显升高(P<0.05)。结论在MHD患者中血管钙化发生率高,血清OPG水平升高,OPG可能参与了血管钙化的发生及发展。
Objective To observe the serum level of osteoprotegerin in maintenance hemodialysis patients and to explore its relationship with vascular calcification. Methods From January 2015 to January 2016, 60 patients undergoing regular hemodialysis in the Department of Hematology and Blood Purification of Weifang People’s Hospital were selected as the research objects and 30 healthy subjects were selected as the control group. The patients in each group were measured by ELISA Serum osteoprotegerin (OPG) levels were measured by X-ray examination of calcification in all groups of patients with vascular calcification, and calculate the various parts of the vascular calcification score. Results According to the X-ray calcification score, 60 patients with MHD were divided into three groups: no calcification group (0 points, 21 cases, accounting for 35% of the total MHD), mild calcification group (~ 3 points, 38.3% of the population), moderate calcification group (~ 6 points, 11 cases, accounting for 18.3% of the total number of MHD) and severe calcification group (~ 10 points, 5 persons, accounting for 8.4% of the total number of MHD) The control group did not have vascular calcification. In patients with MHD, the level of OPG in vascular calcification group was significantly higher than that in non-vascular calcification group (P <0.05). The levels of OPG in moderate and severe vascular calcification group were significantly higher than those in non-calcified or mild calcified group (P <0.05). Conclusions In patients with MHD, the incidence of vascular calcification is high and serum OPG level is elevated. OPG may be involved in the occurrence and development of vascular calcification.