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目的:探讨胎膜早破及其绒膜羊膜炎时孕妇血和脐血白细胞介素-8(interleukin-8,IL-8)的意义。方法:采用放射免疫法对30例胎膜早破孕妇血和脐血进行IL-8的测定,并以正常足月妊娠孕妇20例做对照。组织绒膜羊膜炎通过产后胎盘病理确诊。结果:胎膜早破孕妇血和脐血IL-8的水平明显高于对照组(P<0.01～0.02),随着破膜时间延长IL-8升高,且时间超过30小时IL-8明显升高,绒膜羊膜炎患者孕妇血和脐血IL-8与非绒膜羊膜炎比较,有显著差异(P<0.001)孕妇血和脐血IL-8的变化与产力无关(P>0.05),两组孕妇血和脐血IL-8水平呈正相关(P<0.001)。结论:孕妇血IL-8的浓度可作为足月胎膜早破组织绒膜羊膜炎筛选的一个指标。
Objective: To investigate the significance of interleukin-8 (IL-8) in pregnant women’s blood and umbilical cord blood during premature rupture of membranes and their meningitis. Methods: Radioimmunoassay was used to detect IL-8 levels in 30 cases of premature rupture of membranes and 20 cases of normal pregnant women. Membranous meningitis is diagnosed by placenta pathology. Results: The level of IL-8 in blood and umbilical cord blood of pregnant women with premature rupture of membranes was significantly higher than that of the control group (P <0.01-0.02). IL-8 increased with the prolongation of rupture time and more than 30 hours (P <0.001). The changes of IL-8 in blood and umbilical cord blood were not related with the labor force (P> 0.05) ). There was a positive correlation between serum IL-8 level in cord blood and umbilical cord blood (P <0.001). Conclusion: The concentration of blood IL-8 in pregnant women can be used as a screening index for ruptured membranes of full-term premature rupture of membranes.