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目的探讨体外受精-胚胎移植(IVF-ET)新鲜胚胎移植(f ET)及冻融胚胎移植(FET)对妊娠结局的影响。方法对2010年1月至2014年3月北京大学人民医院接受IVF-ET治疗的1 516例单胎妊娠分娩患者进行回顾性研究,比较f ET及FET的临床妊娠率、妊娠期并发症、围生儿结局等。结果 1 516例IVF-ET单胎分娩患者中,85例合并内科相关疾病,929例(61.3%)接受f ET治疗(f ET组),587例(38.7%)接受FET治疗(FET组)。f ET组前置胎盘发生率(1.8%,17/929)与FET组(4.3%,25/587)比较,差异有统计学意义(P<0.05);f ET组产后出血发生率(5.0%,46/929)与FET组(9.2%,54/587)比较,差异有统计学意义(P<0.05)。f ET组胎盘粘连发生率(1.1%,10/929)与FET组(2.9%,17/587)比较,差异有统计学意义(P<0.05)。logistic回归分析显示,FET是产后出血、胎盘粘连发生的独立危险因素(OR=1.603、OR=2.828,P均<0.05),两组其他并发症比较,差异无统计学意义(P>0.05)。结论 FET较f ET可能增加患者妊娠期并发症的发病风险。
Objective To investigate the effect of fresh embryo transfer (IVF-ET) and embryo transfer (FET) on pregnancy outcomes. Methods A retrospective study of 1 516 cases of singleton pregnancies delivered by Peking University People’s Hospital from January 2010 to March 2014 was conducted. The clinical pregnancy rates, gestational complications, f And so on. Results Among 1 516 IVF-ET single-childbirth patients, 85 had medical-related diseases, 929 (61.3%) received f ET and 587 (38.7%) received FET. (P <0.05). The incidence of postpartum hemorrhage (5.0%) in f ET group was significantly higher than that in FET group (4.3%, 25/587) , 46/929) compared with FET group (9.2%, 54/587), the difference was statistically significant (P <0.05). The incidence of placenta accreta in ET group (1.1%, 10/929) was significantly higher than that in FET group (2.9%, 17/587) (P <0.05). Logistic regression analysis showed that FET was an independent risk factor for postpartum hemorrhage and placenta adhesion (OR = 1.603, OR = 2.828, P <0.05). There was no significant difference between the two groups in other complications (P> 0.05). Conclusion FET may increase the risk of complications during pregnancy compared with f ET.