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本文对经紫外线灭活HSV—2(吴株)致癌潜力进行了实验观察,结果存活一年的紫外线灭活组动物癌发率为25.00％(12/48),未经灭活的对照组为6.66％(3/45)、经超几何概率法检验,p<0.01(p=0.001186)、有高度显著性差异。经定量紫外线灭活后的HSV—2可以提高小白鼠诱癌率的机制、可能是由于HSV—2经紫外线灭活处理后,因损害而成为缺陷性病毒,其溶细胞能力被破坏。致使其转化基因得以表现,导致成癌。本实验提示阴部疱疹病毒的感染与整个生殖道肿瘤发生有关,可能与实验感染的方法有关。
In this paper, the oncogenic potential of HSV-2 (Wu strain) was tested by ultraviolet light. The results showed that the incidence of carcinogenesis in UV-inactivated group was 25.00% (12/48), the control group without inactivation was 6.66% (3/45). The hypergeometric probability test showed p <0.01 (p = 0.001186), with a highly significant difference. HSV-2 after UV-inactivation can increase the cancer-inducing rate in mice. This may be due to the fact that HSV-2 is a defective virus after being inactivated by UV light and the cytolytic ability of HSV-2 is destroyed. Resulting in its expression of the transformed gene, leading to cancer. This experiment suggests that genital herpes virus infection and the entire reproductive tract cancer, may be related to experimental infection.