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目的：为了解非淋菌性尿道炎和条件致病菌感染的关系。方法：采用常规细菌培养、Ｋ－Ｂ药敏试验法、支原体培养及衣原体直接免疫荧光染色法检测患者尿道分泌物或前列腺液标本。结果：２３８例非淋菌性尿道炎病人标本中，细菌培养阳性２１１例（８８．６％）；支原体培养阳性３７例（１５．６％），其中与细菌共同阳性３０例；衣原体阳性２４例（１０．８％），其中与细菌共同阳性１４例，与念珠菌共同阳性１例；念珠菌阳性７例。细菌阳性标本共分离到细菌２３９株，除金黄色葡萄球菌（８６株）外，主要细菌还包括棒状杆菌属（４８株），凝固酶阴性葡萄球菌（３３株），链球菌属（１９株），大肠埃希氏菌（１５株）及假单胞菌属等，均为条件致病菌，而且对常用抗生素存在不同程度耐药株。结论：这些条件致病菌应考虑是非淋菌性尿道炎的病原菌，具有单独或混合引起感染的可能性。
Objective: To understand the relationship between non-gonococcal urethritis and opportunistic pathogen infection. Methods: Urethral secretions or prostatic fluid samples were detected by routine bacterial culture, K-B susceptibility test, mycoplasma culture and direct immunofluorescence staining of chlamydia. Results: Of the 238 non-gonococcal urethritis patients, 211 (88.6%) were positive for bacterial culture, 37 (15.6%) were positive for mycoplasma, 30 were positive for bacteria, 24 were positive for chlamydia 10.8%), of which 14 were positive with bacteria and 1 was positive with Candida; 7 were positive Candida. 239 bacteria were isolated from bacteria-positive specimens. Staphylococcus aureus (48 strains), coagulase-negative staphylococci (33 strains), Streptococcus (19 strains) , Escherichia coli (15 strains) and Pseudomonas, etc., are opportunistic pathogens, but there are varying degrees of resistant strains of commonly used antibiotics. CONCLUSIONS: These opportunistic pathogens should be considered pathogens of non-gonococcal urethritis with the potential to cause infection either alone or in combination.