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目前乙肝疫苗接种重点是新生儿、血液制品使用者及与传染源密切接触的人群,但对一般人群的应用价值尚需进一步研究.我们对乙肝疫苗接种者的免疫应答状况及有关因素进行了分析,报告如下:1 材料和方法1.1 接种对象 5项乙肝血清学指标全部阴性者有203人,其中男性142人,女性61人.年龄21-60岁,平均年龄42.5岁.1.2 接种方法 分每人70μg和每人90μg两种剂量组.前者按30—30—10μg,后者按30—30—30μg分三次上臂三角肌注射.两组均按0—1—6月免疫程序接种.疫苗为卫生部上海生物制品研究所产品.1.3 抗HBs抗体测定 疫苗第三针接种后三个月采血分离血清,采用上海实业科华生物技术有限公司产品作ELISA检测,以抗HBs阳性率反映抗体应答能力.2 结果2.1 乙肝疫苗接种者的免疫应答 如表1所示,203例成人乙肝疫苗接种后产生抗HBs者140例,总应答率达(69.0%).男性应答率(70.4%)与女性(65.5%)无明显差异(P>0.05).按不同年龄组分析,发现随年龄增长,应答能力逐渐减弱;年龄与应
At present, hepatitis B vaccination focuses on newborns, blood products users and people in close contact with the source of infection, but the value of the general population needs further study.We conducted an analysis of the status of hepatitis B vaccine immunization and related factors , The report is as follows: 1 Materials and methods 1.1 Inoculum 5 hepatitis B serological indicators were negative in all 203 people, including 142 males and 61 females, aged 21-60 years, with an average age of 42.5 years.1.2 The method of vaccination per person 70μg and 90μg per person in two dose groups.The former by 30-30-10μg, the latter by 30-30-30μg divided into three upper arm deltoid muscle injection.The two groups were vaccinated according to 0-1-6 month vaccination program.The vaccine was health Department of Shanghai Institute of Biological Products .1.3 anti-HBs antibody assay Vaccine three months after inoculation blood collection serum, the Shanghai Industrial Co., Ltd. Kehua Biotechnology Co., Ltd. for ELISA testing to anti-HBs positive rate reflects the ability of antibody response. 2 Results 2.1 Immune response of hepatitis B vaccine recipients As shown in Table 1, 140 cases of anti-HBs were produced in 203 adults with the overall response rate (69.0%). The male response rate (70.4%) and female 5.5%) (P> 0.05) .According to age group analysis, we found that with the increase of age, the response ability gradually weakened; age and response