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目的:观察干扰素α-1b治疗轮状病毒肠炎的临床疗效。方法:选择2011年10月至2012年2月我院门诊就诊的轮状病毒肠炎患儿86例,按随机数表法分成治疗组45例和对照组41例。两组病例根据脱水程度及性质给予口服或静脉补液,并口服双歧杆菌三联活菌、蒙脱石散、腹泻奶粉;治疗组在此基础上给予肌肉注射重组人干扰素α-1b,6月～1岁,每次6μg,每天1次,>1岁～2岁,每次10μg,每天1次,连续3 d;对照组给予利巴韦林注射液10 mg/(kg.d)静脉滴注,每天1次,连续3 d。比较两组的有效率、止泻时间和退热时间。结果:经72 h治疗后,治疗组总有效率93.3%,对照组73.2%,两组比较差异有统计学意义(χ2=5.005,P<0.05);治疗组平均退热时间(1.47±0.46)d,平均止泻时间(3.14±0.68)d,对照组平均退热时间(2.74±1.16)d,平均止泻时间(4.12±1.26)d,两组比较差异均有统计学意义(t=6.791,t=4.537,P均<0.01)。结论:干扰素治疗轮状病毒肠炎可显著提高疗效,缩短病程。
Objective: To observe the clinical efficacy of interferon α-1b in the treatment of rotavirus enteritis. Methods: From October 2011 to February 2012, 86 children with rotavirus enteritis in our hospital were divided into treatment group (n = 45) and control group (n = 41) by random number table. Two groups of patients according to the degree of dehydration and the nature of oral or intravenous rehydration and oral live Bifidobacterium triple viable, montmorillonite powder, diarrhea milk powder; the treatment group on this basis, intramuscular injection of recombinant human interferon α-1b, June ~ 1 year old, 6μg each time, once a day,> 1 year old to 2 years old, each 10μg, once a day for 3 days. The control group was given ribavirin 10 mg / (kg.d) Note, 1 day, for 3 days. Efficacy, antidiarrheal time and antipyretic time were compared between the two groups. Results: After 72 h treatment, the total effective rate was 93.3% in the treatment group and 73.2% in the control group, with significant difference between the two groups (χ2 = 5.005, P <0.05); the average antipyretic time in the treatment group was 1.47 ± 0.46 The mean time to antidiarrheal (3.14 ± 0.68) d, control group average antipyretic time (2.74 ± 1.16) d, average antidiarrheal time (4.12 ± 1.26) d, the difference between the two groups were statistically significant (t = 6.791 , t = 4.537, P <0.01). Conclusion: Interferon treatment of rotavirus enteritis can significantly improve the efficacy and shorten the course of disease.