多发性硬化(MS)是免疫介导的神经系统疾病,目前有学者认为MS是一种获得性离子通道病。离子通道表达异常主要为神经元、神经轴膜上离子通道数量、空间分布、表达模式的改变,其次是干扰免疫细胞介导的炎症反应,导致脱髓鞘、轴突变性。离子通道阻滞剂(ion channel blocker)已被证实具有改善MS临床症状的作用。 Multiple sclerosis (MS) is an immune-mediated neurological disease. At present, some scholars think that MS is an acquired ion channel disease. The abnormal expression of ion channels is mainly the number of neuronal cells, the number of ion channels on the axons, the spatial distribution and the expression pattern of the ion channels, followed by the interference of immune cell-mediated inflammatory responses, leading to demyelination and axonal degeneration. Ion channel blockers have been shown to improve the clinical symptoms of MS.