Graves病(GD)的甲状腺机能亢进常由于 甲状腺部分切除而得到持久性缓解,其原因迄今仍 未阐明。显然,早期的反应是由于切除了分泌甲状 腺激素过多的组织,可是,GD的甲状腺机能亢进 是由于甲状腺刺激抗体(TSAb)与甲状腺细胞膜 受体相互作用的结果,而术后,循环的淋巴细胞衍 生抗体将会继续刺激残留的甲状腺,促进其生长和 分泌激素,最终导致复发甲状腺机能亢进,但复发 却极少见。而且手术后TSAb滴度有下降趋向,在 几个月内常常检测不出,这表明甲状腺本身能以某 Hyperthyroidism in Graves’ disease (GD) is often persisted due to partial thyroidectomy, the reason why so far has not yet been elucidated. Obviously, the early response was due to excision of tissues secreting excessive thyroid hormones. However, hyperthyroidism in GD is due to the interaction of thyroid stimulating antibody (TSAb) with thyroid cell membrane receptors, whereas postoperative circulating lymphocytes Derived antibodies will continue to stimulate the residual thyroid, promote its growth and secretion of hormones, and ultimately lead to recurrent hyperthyroidism, but recurrence is rare. And TSAb titers have decreased after surgery, often undetectable within a few months, suggesting that the thyroid itself to a certain