目的:了解南充市女性群体高危型人乳头瘤病毒(HR-HPV)的感染情况,为预防HR-HPV的感染、HPV疫苗的选择等提供科学依据.方法:收集2018年1月至2019月12月南充市中心医院妇科门诊、体检、住院等7475例患者的HR-HPV检查结果,进行统计学分析.结果:7475例研究对象中HR-HPV阳性者1487例,感染率19.89％;将感染概率按高低排序,前8位顺序为52型、16型、58型、51型、39型、68型、18型、56型;HR-HPV感染以单一感染多见,占78.68％;不同年龄段HR-HPV感染率“,”Objective:To understand the infection status of high-risk human papillomavirus (HR-HPV) among female populations in Nanchong, and to provide scientific basis for the prevention of HR-HPV infection and the selection of HPV vaccines.Methods The HR-HPV examination results of 7475 patients in the gynecological clinic, physical examination, and hospitalization of Nanchong Central Hospital from January 2018 to December 2019 were collected and statistically analyzed.Results Among the 7475 subjects, 1487 were HR-HPV positive, and the infection rate was 19.89％; the infection probability was ranked by high and low, and the top 8 were type 52, type 16, type 58, 51, type 39, type 68, 18 Type 56; HR-HPV infection is more common in single infection, accounting for 78.68％ ; HR-HPV infection rate is different in different age groups, with the highest infection rate between 46-55 years old.Conclusion The infection rate of HR-HPV among females in Nanchong is high, and single infection is the main one. HPV 52, 16, 58, and 51 are the key points to prevent infection. It is recommended that the HPV vaccine be inoculated with a nine-valent vaccine.