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目的:探讨甲状腺乳头状癌(PTC)中存活素(Survivin)、血管内皮生长因子(VEGF)、表皮生长因子受体(EGFR)的表达及临床意义。方法:选择2013年4月~2016年4月在我院收治的100例PTC患者的手术标本以及同期100例癌旁正常甲状腺组织为研究对象,采用免疫组化方法检测盒比较Survivin、VEGF、EGFR的表达在PTC及癌旁正常甲状腺组织中的表达及二者的相关性,并分析其Survivin、VEGF、EGFR的表达与PTC患者临床病理特征的相关性。结果:PTC组织中Survivin、VEGF、EGFR阳性表达率均显著高于癌旁正常甲状腺组织,差异具有统计学意义(P<0.05);Survivin、VEGF在淋巴结转移患者中的阳性表达率显著高于无淋巴结转移者(P<0.05);EGFR在女性PTC患者中的阳性表达率显著高于男性(P<0.05)。PTC组织中VEGF和Survivin、EGFR的表达无显著相关性(P>0.05),但Survivin和EGFR的表达显著相关(r=0.235,P<0.05)。结论:Survivin、VEGF、EGFR在PTC组织中表达上调,Survivin、VEGF与PTC的淋巴结转移有关,Survivin和EGFR在PTC的发生、发展过程中可能存在着协同作用。
Objective: To investigate the expression of survivin, vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) in papillary thyroid carcinoma (PTC) and its clinical significance. Methods: A total of 100 surgical specimens from PTC patients treated in our hospital from April 2013 to April 2016 were enrolled in this study. 100 cases of normal thyroid tissue adjacent to the tumor were selected as the study objects. Survivin, VEGF and EGFR were detected by immunohistochemistry And its correlation with the expression of Survivin, VEGF and EGFR in PTC and paracancer normal thyroid tissue and the clinicopathological features of PTC. Results: The positive rates of Survivin, VEGF and EGFR in PTC tissues were significantly higher than those in normal thyroid tissues (P <0.05). The positive rates of Survivin and VEGF in patients with lymph node metastasis were significantly higher than those without Lymph node metastasis (P <0.05). The positive expression rate of EGFR in women with PTC was significantly higher than that in men (P <0.05). There was no significant correlation between the expression of VEGF and Survivin and EGFR in PTC (P> 0.05), but there was a significant correlation between Survivin and EGFR expression (r = 0.235, P <0.05). CONCLUSIONS: Survivin, VEGF and EGFR are upregulated in PTC. Survivin and VEGF are associated with lymph node metastasis in PTC. Survivin and EGFR may play synergistic roles in the development and progression of PTC.