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目的 :观察消痞灵对慢性萎缩性胃炎 (CAG)大鼠胃粘膜组织细胞 DNA含量和细胞动力学的影响。方法 :将大鼠随机分 5组 ,采用乙醇和脱氧胆酸钠复合造模法。留取胃粘膜组织块 ,流式细胞仪检测 DI及 PI,并分析细胞周期变化情况。结果 :消痞灵大、小剂量组 DI值与模型组有显著差异 ;模型组 G0 /1期细胞比率明显低于正常组和消痞灵组 ,而 S组和 G2 /M期细胞比率明显高于正常组和消痞灵组 ;模型组 PI值明显高于消痞灵组。结论 :消痞灵对 CAG大鼠胃粘膜活跃的增殖状态有明显抑制作用
Objective: To observe the effect of Xiaozhiling on cell DNA content and cell dynamics in gastric mucosa of chronic atrophic gastritis (CAG) rats. Methods : The rats were randomly divided into 5 groups, using ethanol and sodium deoxycholate composite molding method. Gastric mucosal tissue blocks were collected, DI and PI were detected by flow cytometry, and changes in cell cycle were analyzed. RESULTS: There was a significant difference between the DI value in the large and small doses of Xiaozhiling and the model group; the ratio of G0/1 phase cells in the model group was significantly lower than that in the normal group and Xiaozhiling group, while the ratio of cells in the S group and G2 /M phase was significantly higher. In the normal group and Xiaozhiling group, the PI value of the model group was significantly higher than that of the Xiaozhiling group. Conclusion: Xiaozhiling has a significant inhibitory effect on the active proliferation of gastric mucosa in CAG rats