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NK细胞亚群不同表型间存在效应功能的差异,在组织器官的分布也有显著差别。研究证明,肝脏、胸腺、肺脏、子宫、皮肤等组织内存在居留NK细胞,其发育、表型及功能与骨髓中发育、成熟后迁入外周器官的传统NK细胞不同,在维持组织稳态、调控多种重要病理生理过程中发挥作用,与Ⅰ类固有样淋巴细胞具有部分重叠又不完全相同的表型及功能,并且与诱导NK细胞记忆性相关。针对NK细胞尤其是居留NK细胞的研究将为肿瘤免疫治疗提供新的机遇。
There were significant differences in the distribution of NK cell subsets among different phenotypes in the distribution of tissues and organs. Studies have shown that there are resident NK cells in the liver, thymus, lung, uterus, skin and other tissues. Its development, phenotype and function are different from the traditional NK cells that move into the peripheral organs after maturation and maturation. While maintaining the homeostasis, Regulate a variety of important pathophysiological processes play a role, with type I innate lymphoid cells have some overlap and not exactly the same phenotype and function, and with the induction of NK cell memory related. Research on NK cells, especially resident NK cells, will provide new opportunities for tumor immunotherapy.