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探讨运动神经元病与免疫的关系。方法对３７例临床确诊为运动神经元疾病的患者进行血清可溶性白细胞介素－２受体（ｓＩＬ－２Ｒ）检测。结果（１）全部运动神经元疾病患者治疗前血清中ｓＩＬ－２Ｒ水平与正常对照组无显著差异，其中肌萎缩侧索硬化症组和进行性延髓麻痹组血清ｓＩＬ－２Ｒ水平明显增高，但进行性脊肌萎缩症组与正常对照组间无显著差异。（２）经强的松治疗４周后的１６例患者血清ｓＩＬ－２Ｒ水平明显下降。结论运动神经元病存在一定的免疫异常，ｓＩＬ－２Ｒ水平可能与运动神经元疾病的状态有密切关系。
To explore the relationship between motor neuron disease and immunity. Methods Serum soluble interleukin-2 receptor (sIL-2R) was detected in 37 patients with motor neuron disease. Results (1) Serum levels of sIL-2R in patients with motor neuron disease before treatment were not significantly different from those in the normal control group. Serum levels of sIL-2R in amyotrophic lateral sclerosis group and progressive bulbar palsy group were significantly increased There was no significant difference between normal spinal cord atrophy group and normal control group. (2) Serum sIL-2R levels were significantly decreased in 16 patients after prednisone treatment for 4 weeks. Conclusion There is a certain degree of immunological abnormalities in motor neuron disease. The level of sIL-2R may be closely related to the state of motor neuron disease.