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目的 :检测MUC1在胃癌及胃良性病变组织中的表达 ,探讨其在胃癌诊断和免疫治疗中的意义 .方法 :采用免疫组化方法检测 5 8例胃癌及 2 6例胃良性病变组织、1 0例胃正常组织中MUC1的表达 .结果 :胃癌组织中MUC1阳性表达4 6例 ,为深棕色或棕黄色颗粒 ,主要位于细胞核上 ;良性病变组织中 4例可见弱阳性反应信号 ;正常胃组织中未见MUC1表达 .MUC1在胃癌组织中的阳性表达率与胃良性病变组织及正常组织之间存在显著性差异 (P <0 .0 5 ) .MUC1基因表达与组织学分化及部位无关 (P >0 .0 5 ) ;与组织浸润转移及与临床分期有关 (P <0 .0 5 ) .结论 :MUC1在胃癌组织中的表达及分布特点可作为胃癌的鉴别诊断指标 ,有可能作为胃癌免疫治疗的靶分子
Objective: To detect the expression of MUC1 in gastric cancer and gastric benign lesions, and to explore the significance of MUC1 in the diagnosis and immunotherapy of gastric cancer.Methods: Immunohistochemical methods were used to detect the expression of MUC1 in 58 cases of gastric cancer and 26 cases of gastric benign lesions, The expression of MUC1 in normal gastric tissue was analyzed.Results: The MUC1 positive expression in gastric cancer tissues was 46 cases, dark brown or brown granules, mainly located in the nucleus; weak positive reaction signal was seen in 4 cases of benign lesions; MUC1 expression was not found in gastric cancer tissues and gastric benign lesions and normal tissues there was a significant difference (P <0.05) .MUC1 gene expression and histological differentiation and site unrelated (P> (P <0.05) .Conclusion: The expression and distribution of MUC1 in gastric cancer can be used as a differential diagnosis indicator of gastric cancer, which may be used as a gastric cancer immunotherapy Of target molecules