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目的 研究急性一氧化碳中毒 (ACOP)患者血清C反应蛋白 (CRP)的变化及其临床意义。方法 根据患者入院时中毒的程度设轻度中毒组、中度中毒组、重度中毒组和健康对照组。ACOP中毒患者入院第 1、3、5天抽静脉血检测。结果 入院第 1天、第 3天 ,中度中毒组和重度中毒组血清CRP水平显著高于健康对照组 (P <0 0 5和P <0 0 1) ,轻度中毒组与健康对照组比较 ,无显著性差异 (P <0 0 5 )。第 5天中度中毒组CRP水平与健康组比较无显著性差异 (P <0 0 5 )。而第 5天重度中毒组CRP水平仍显著高于健康对照组 (P <0 0 1)。第 1、3、5天中度中毒组CRP水平与轻度中毒组比较 ,相对应第 1天、第 3天有显著性差异 (P <0 0 1和P <0 0 5 ) ,第 5天无显著性差异 (P >0 0 5 ) ,重度中毒组第 1、3、5天CRP水平与中度中毒组相对应各天比较 ,均有显著性差异 (P <0 0 1)。结论 ACOP患者血清CRP水平与中毒的程度及组织损伤的病理过程相一致 ,可作为ACOP患者诊疗的重要参考指标之一。
Objective To study the changes of serum C-reactive protein (CRP) in patients with acute carbon monoxide poisoning (ACOP) and its clinical significance. Methods According to the degree of poisoning on admission, patients were divided into mild poisoning group, moderate poisoning group, severe poisoning group and healthy control group. ACOP poisoning patients admitted to hospital 1,3,5 days venous blood test. Results On the first day and the third day after admission, the serum levels of CRP in moderate poisoning group and severe poisoning group were significantly higher than those in healthy control group (P <0.05 and P <0.01), respectively. Compared with healthy control group, , No significant difference (P <0 05). On the fifth day, there was no significant difference in CRP level between moderate poisoning group and healthy group (P <0.05). On the fifth day, the level of CRP in severe poisoning group was still significantly higher than that in healthy control group (P <0.01). On the 1st, 3rd and 5th day, the CRP level in the moderate poisoning group was significantly different from that in the mild poisoning group on the first day and the third day (P <0.01 and P <0.05), on the fifth day There was no significant difference between the two groups (P> 0.05). The levels of CRP on the 1st, 3rd and 5th days in severe poisoning group were significantly different from those in moderate poisoning group (P <0.01). Conclusion The level of serum CRP in ACOP patients is consistent with the degree of poisoning and the histopathological process of tissue damage, which can be used as one of the important reference indexes for the diagnosis and treatment of ACOP.