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目的探讨在普通人群中药物性低镁血症的特点及规律,为临床早期诊断和治疗提供依据。方法回顾分析2009年1月1日至2011年1月1日期间收治的27例药物性低镁血症患者的临床资料。结果本组27例药物性低镁血症中,女性15例,男性12例(1.25:1);年龄16～76岁。致病药物中利尿药物居首位,其次分别为抗病毒类药物、抗肿瘤类药物、免疫抑制剂及抗寄生虫类药物等。结论对临床药物所致低镁血症,首要应以预防为主,一旦确诊,应及时补充镁盐,但完全补足体内缺镁需时较长,需解除症状后持续补镁1～3周。
Objective To explore the characteristics and laws of drug-induced hypomagnesemia in the general population and provide the basis for early clinical diagnosis and treatment. Methods The clinical data of 27 patients with drug-induced hypomagnesemia admitted from January 1, 2009 to January 1, 2011 were retrospectively analyzed. Results The group of 27 cases of drug-induced hypomagnesemia, 15 females, 12 males (1.25: 1); aged 16 to 76 years. Pathogenic drugs diuretic drugs in the first place, followed by anti-viral drugs, anti-tumor drugs, immunosuppressive agents and anti-parasitic drugs. Conclusions The main cause of hypomagnesemia caused by clinical drug should be prevention first. Once diagnosed, magnesium salt should be replenished promptly. However, it takes a long time to complete magnesium deficiency in vivo, and magnesium should be continuously supplemented for 1 to 3 weeks after the symptoms are relieved.