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目的观察小剂量阿司匹林对冠心病患者血清脂蛋白(a)[Lp(a)]的影响。方法采用酶联免疫双抗体夹心法分别检测30例血清Lp(a)浓度升高的冠心病患者和32例正常血清Lp(a)浓度的对照者连续服用小剂量阿司匹林(100mg/d)1个月及3个月后的血清Lp(a)浓度。结果高血清Lp(a)浓度和正常血清Lp(a)浓度冠心病患者服用阿司匹林前浓度分别为(511±51.7)和(125.9±15.1),服药后高血清Lp(a)组患者1个月及3个月的血清Lp(a)浓度分别为(475.2±23.5)和(437.4±21.8)平均浓度大约下降了7%(P<0.05)。正常血清Lp(a)浓度变化不明显,分别为(118.6±13.4)和(119.8±13.7)。结论小剂量阿司匹林(100mg/d)能有效的降低高血清Lp(a)浓度冠心病患者血清Lp(a)水平,而对正常血清Lp(a)的冠心病患者无明显影响。
Objective To observe the effects of low-dose aspirin on serum lipoprotein (a) [Lp (a)] in patients with coronary heart disease. Methods A total of 30 CHD patients with elevated serum Lp (a) concentration and 32 healthy persons with Lp (a) serum concentration were enrolled in this study. One dose of aspirin (100mg / d) Month and 3 months after the serum Lp (a) concentration. Results Serum concentrations of Lp (a) and normal serum Lp (a) before taking aspirin were (511 ± 51.7) and (125.9 ± 15.1), respectively, and those in high serum Lp (475.2 ± 23.5) and (437.4 ± 21.8), respectively, decreased by about 7% (P <0.05). The normal serum Lp (a) concentration did not change significantly, respectively (118.6 ± 13.4) and (119.8 ± 13.7). Conclusions Low - dose aspirin (100mg / d) can effectively reduce serum Lp (a) levels in patients with coronary heart disease in patients with Lp (a) high serum concentration, but not in patients with coronary artery disease with normal serum Lp (a).