论文部分内容阅读
幽门螺杆菌与胃癌的发生密切相关。幽门螺杆菌感染能促进细胞端粒酶活化 ,胃组织EGF与EGFR表达增高 ,引起胃粘膜上皮细胞增殖加速 ,也能促使细胞凋亡的增加 ,加快胃上皮细胞的转换 ,导致细胞周期调控机制发生改变 ;幽门螺杆菌感染可使胃酸分泌减少 ,分解硝酸盐细菌在胃内滋生 ,使胃内具有致癌作用的亚硝基化合物形成增加 ,参与细胞的癌变。这些研究均提示幽门螺杆菌感染可能通过多种分子机制参与胃癌的癌变。
Helicobacter pylori and gastric cancer are closely related. Helicobacter pylori infection can promote the activation of telomerase, increase the expression of EGF and EGFR in gastric tissue, accelerate the proliferation of gastric mucosal epithelial cells, promote the apoptosis of gastric epithelial cells and accelerate the transformation of gastric epithelial cells, resulting in the occurrence of cell cycle regulatory mechanisms Change; Helicobacter pylori infection can reduce gastric acid secretion, decomposition of nitrate bacteria in the stomach breeding, the stomach carcinogenesis of nitroso compounds formation, involved in cancer cells. These studies suggest that H. pylori infection may be involved in the carcinogenesis of gastric cancer through a variety of molecular mechanisms.