目的　介绍转化生长因子 β(TGF β)及其与移植排斥的关系。 方法　复习近年相关文献并加以综述。结果　TGF β的免疫抑制作用可对抗移植器官在移植术早期遭受的排斥损伤 ;同时TGF β能促进成纤维细胞分化 ,增加胶原生成 ,抑制胶原酶活性而降低胶原的分解 ,促进基质沉淀 ,引起移植器官纤维化及动脉粥样硬化 ,TGF β的基因多态性与此密切相关。此外 ,缺血再灌注损伤、免疫抑制剂亦对TGF β的合成产生影响。 结论　TGF β是一种具有多向性和多种功能的细胞因子 ,与急、慢性排斥反应的发展有关 Objective To investigate the relationship between transforming growth factor β (TGF β) and graft rejection. Methods Review the recent literature and review. Results The immunosuppressive effect of TGF β could antagonize the rejection injury of transplanted organs in the early stage of transplantation. At the same time, TGF β could promote fibroblast differentiation, increase collagen production, inhibit collagenase activity and reduce the decomposition of collagen, promote matrix deposition and induce transplantation Organ fibrosis and atherosclerosis, TGFβ gene polymorphism and this are closely related. In addition, ischemia-reperfusion injury, immunosuppressive agents also affect TGFβ synthesis. Conclusion TGF β is a multi-directional and multi-functional cytokine, which is related to the development of acute and chronic rejection