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目的观察自拟解郁安神汤结合盐酸帕罗西汀胶囊治疗中风后抑郁症的临床疗效。方法将80例患者随机分为治疗组和对照组(各40例),对照组予盐酸帕罗西汀胶囊,治疗组在此基础上加服自拟解郁安神汤;两组疗程均为8周,观察临床疗效及治疗后汉密尔顿抑郁量表(HAMD)评分、去甲肾上腺素(NE)、5-羟色胺(5-HT)变化情况。结果治疗组、对照组总有效率分别为90.0%、72.5%;组间临床疗效比较,差异有统计学意义(P<0.05)。两组治疗后HAMD评分明显减少(P<0.05);组间治疗后比较,差异有统计学意义(P<0.05)。两组治疗后5-HT、HE水平均明显提高(P<0.05);组间治疗后比较,差异均有统计学意义(P<0.05)。结论解郁安神汤结合盐酸帕罗西汀胶囊治疗中风后抑郁症疗效明显优于单用盐酸帕罗西汀胶囊,且无明显不良反应。
Objective To observe the clinical efficacy of self-made Jieyu Anshen Decoction combined with paroxetine hydrochloride in the treatment of post-stroke depression. Methods Eighty patients were randomly divided into treatment group and control group (40 cases each). The control group was given Paroxetine Hydrochloride Capsules. On the basis of this, the treatment group added self-made Jieyu Anshen Decoction. The two courses of treatment were 8 weeks, To observe the clinical curative effect and the Hamilton Depression Rating Scale (HAMD) score, norepinephrine (NE) and 5-hydroxytryptamine (5-HT) after treatment. Results The total effective rates of the treatment group and the control group were 90.0% and 72.5%, respectively. There was significant difference between the two groups in clinical efficacy (P <0.05). The HAMD scores of the two groups were significantly decreased after treatment (P <0.05). There was significant difference between the two groups after treatment (P <0.05). After treatment, the levels of 5-HT and HE in both groups were significantly increased (P <0.05). After treatment, the differences were statistically significant (P <0.05). Conclusions Jieyu Anshen Decoction combined with paroxetine hydrochloride capsule in the treatment of depression after stroke is obviously superior to paroxetine hydrochloride capsules alone, and no obvious adverse reactions.