雌性小鼠尾静脉按剂量200μCi/kg(5mg/kg)注射~3H-R2323乙醇溶液。其血浆中药物浓度的动力学变化符合三(尸方)室模型,各相半衰期分别为T~1/2π=4.78min,T~1/2α=1.90hr,T~1/β=8.83d,中心室分布容积V_c=77.2ml/kg。小鼠口服~3H-R2323乙醇溶液,血药-时曲线的动力学变化显示,达峰时T_m=1d,峰浓度C_m=22.1μg/ml。实验所用制剂的生物利用度为39.6%。高压液相结果表明R2323注入动物体内后在2h内主要以原形存在。 Female mice were injected a ~ 3H-R2323 ethanol solution into the caudal vein at a dose of 200 μCi / kg (5 mg / kg). The pharmacokinetic changes of the drug concentration in plasma were in accordance with the three-compartment model. The half-lives of each phase were T 1 / 2π = 4.78min, T 1 / 2α = 1.90hr, T 1 / β = 8.83d, Center room distribution volume V_c = 77.2ml / kg. Mice oral ~ 3H-R2323 ethanol solution, plasma drug-kinetic curve showed that when the peak T_m = 1d, peak concentration C_m = 22.1μg / ml. The bioavailability of the formulations used in the experiment was 39.6%. The results of high pressure liquid phase showed that R2323 mainly existed in shape within 2h after it was injected into animals.