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以乌拉坦１次腹腔注射（５００ｍｇ／ｋｇ）和雌激素每周１次肌肉注射（５０ｍｇ／ｋｇ）诱发小鼠肺肿瘤。以０．０２％及０．２％的茶多酚溶液供小鼠饮用以研究茶多酚对肺肿瘤的抑制作用。１８周后作肺肿瘤病理分析，饮茶多酚组发瘤率和发癌率显著低于阳性对照组，平均肿瘤数和恶性肿瘤比例明显降低。高剂量茶多酚组平均肿瘤数明显低于低剂量茶多酚组。阳性对照组肺肿瘤雌激素受体阳性率为３７．３％，饮用低剂量和高剂量茶多酚可使受体阳性率分别降低到１９．５％与１２．５％。结果提示茶多酚对药物联合诱导的肺肿瘤发生有抑制作用，在肺肿瘤预防上有重要意义。
Mouse lung tumors were induced by once intraperitoneal injection of urethane (500 mg/kg) and estrogen once a week (50 mg/kg). 0.02% and 0.2% tea polyphenol solution was used for mice to study the inhibitory effect of tea polyphenols on lung tumors. After 18 weeks, lung cancer pathology analysis showed that the incidence of tumor growth and cancer incidence in the tea polyphenols group was significantly lower than that in the positive control group, and the average number of tumors and the proportion of malignant tumors were significantly reduced. The average tumor number in the high dose tea polyphenols group was significantly lower than that in the low dose tea polyphenols group. In the positive control group, the positive rate of estrogen receptors in lung tumors was 37.3%, and low-dose and high-dose tea polyphenols could reduce the positive rate of receptors to 19.5% and 12.5%, respectively. The results suggest that tea polyphenols have inhibitory effects on drug-induced lung tumorigenesis and have important implications in the prevention of lung tumors.