【摘 要】
：
Nicotinic acetylcholine receptors (nChRs) are involved in the variouspharmacological effects or disease states. In order to study the central nChRs by PETor SPE
【机 构】
：
Key Laboratory of Radiation Physics and Technology of Education Ministry of China,Chemistry Departme
论文部分内容阅读
Nicotinic acetylcholine receptors (nChRs) are involved in the variouspharmacological effects or disease states. In order to study the central nChRs by PETor SPECT, some radioligands have been investigated. In this paper, the procedurefor synthesis of 2-[18F]fluoro-3-[2(S)-2-azetidinylmethoxy]pyridine (2-[18F]-A-85380), apotential PET ligand for in vivo imaging nicotinic acetylcholine receptor was described.2-[18F]-A-85380 was prepared from the precursor, 2-nitro-3-[(1-(tert-butoxycarbonyl)-2-(S)-azetidinyl)methoxy]pyridine(4), which was synthesized with commercial (S)-2-azetid- inecarboxylic acid as starting material. The whole procedure for radiosynthesisand purification was executed in about lh and 45-55% of the added fluorine-18 wasfound in the purified 2-[18F]-A-85380, with specific activity of 1.0-2.2 × 1011 Bq/μmol.``
其他文献
A newly developed catalyst type DVR- 1 for catalytic cracking of Daqing vacuum resid was put into use in a commercial VRFCC unit. This catalyst features uniquel
掺杂法提高聚合物电导的机理是考虑导电填充物和高聚物所构成的不均匀体系中,导电颗粒间会形成链式组织或聚集体组织而提高导电性能,在此过程中导电颗粒有相互作用.本文是采
A new method for forecasting non stationary series is developed. Its steps are as follows: Step 1. Data delaminating. Non stationary series is delaminated int
This paper combines the film model with Nusselt’s condensation theory to analyze the effects of water vapor condensation on the heat transfer performance of
由JACEE,RUNJOB和SOKOL等宇宙线直接测量结果和刚度截断模型,对于1014-1016eV能区的初级宇宙线微分能谱参数进行调整.利用调整后的能谱与选取QGSJET模型的CORSIKA程序进行EAS
选取辐射Bhabha样本,研究了北京谱仪Ⅱ(BESⅡ)桶部簇射计数器(BSc)对中性径迹的沉积能量和空间位置的测量,定出了实际数据的测量误差.并利用Monte carlo0产生的e+e-→γγ事
It is observed that the regulation sequences at the two ends of every active gene of the heart nuclear DNA fragments may differentially combine with active regu
Explicit analytical solutions are presented for the coupled fluid flow transfer equation in heterogeneous porous media. These analytical solutions are useful fo
We study the parameter estimation in a nonlinear regression model with a general error's structure,strong consistency and strong consistency rate of the least s
利用Belle与CLEO实验组的最新实验数据 ,分析了B→D( ) π衰变道的同位旋振幅与位相差 ,并确定了相关的因子化参数 .结果表明这类衰变道中的强相互作用效应不可忽略 ,但是因