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大肠癌根治术后肝转移发生率甚高,严重影响患者的生存率.鉴于5-Fu静脉全身化疗预防木后肝转移效果不明显,探索新的有效防治途径和方法就显得尤为重要.作者利用裸鼠人结肠癌细胞转移模型研究了术后早期大剂量大容积5-Fu腹腔化疗预防裸鼠经脾内接种人结肠癌细胞肝转移的疗效.结果:(1)肝转移发生率:5-Fu40mg/NS40ml/kg每日一次×2d,腹腔化疗组5-Fu 20mg/NS 40ml/kg每日一次×5d,腹腔化疗组和NS 40ml/kg对照组分别组为60%(6/10)、70%(7/10)和100%(10/10),化
The incidence of hepatic metastasis after radical resection of colorectal cancer is very high, which seriously affects the survival rate of patients. Given the fact that 5-Fu intravenous systemic chemotherapy is not effective in preventing hepatic metastasis after wood, it is particularly important to explore new effective methods and methods of prevention and treatment. Nude mice human colon cancer cell metastasis model Early postoperative large-dose large-volume 5-Fu intraperitoneal chemotherapy was used to prevent hepatic metastasis of human colorectal cancer cells in nude mice. Results: (1) Incidence of liver metastases: 5- 40mg/NS40ml/kg once daily for 2 days, intraperitoneal chemotherapy group 5-Fu 20mg/NS 40ml/kg once daily for 5 days, intraperitoneal chemotherapy group and NS 40ml/kg control group were 60% (6/10), 70% (7/10) and 100% (10/10),